姓名:高如心

职称:特聘副教授

电话:15624961109

邮箱:ruxin1958@163.com

主要学习工作经历

2023-09至今 安徽师范大学,特聘副教授

2018-09 至 2023-07, 中国农业大学, 博士

2014-09 至 2018-06, 中国农业大学, 学士

主要社会兼职

主要研究内容

1.代谢通路关键基因功能及代谢性疾病治疗的分子机制探索

2.食品功能因子功效评价与生物活性机制研究

3.天然产物靶向递送体系的功效验证及体内代谢机制研究

4.食品功能因子相关的功能性食品及特殊医学用途配方食品开发

主要研究课题

1. 国家自然科学基金委员会, 青年科学基金项目(C类)[原青年科学基金项目], 82400672, 非酒精性脂 肪肝病中脂肪酸合酶(FASN)的乳酸化修饰变化和调控机制探索, 2025-01-01 至 2027-12-31, 30万元, 在研, 主持

主要研究成果

一、代表性论文及论著

1.Ruxin Gao#; Yue Li#; Zhimeng Xu; Feng Zhang; Jia Xu; Yanzhou Hu; Jingya Yin; Kun Yang; Lei Sun; Qi Wang; Xiaoyun He; Kunlun Huang ; Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease, Hepatology, 2023, 2023(78): 1800-1815 

2.Xu Chen#; Xiaoyun He#; Ruxin Gao#; Xinyue Lan; Longjiao Zhu; Keren Chen; Yanzhou Hu; Kunlun Huang; Wentao Xu ; Aptamer-Functionalized Binary-Drug Delivery System for Synergetic Obesity Therapy, ACS Nano, 2021, 16(1): 1036-1050  

3.Yanzhou Hu; Jia Xu; Ruxin Gao; Ye Xu; Bingxin Huangfu; Charles Asakiya; Xianghui Huang; Feng Zhang; Kunlun Huang; Xiaoyun He; Yunbo Luo ; Diallyl Trisulfide Prevents Adipogenesis and Lipogenesis by Regulating the Transcriptional Activation Function of KLF15 on PPARγ to Ameliorate Obesity, Molecular Nutrition & Food Research, 2022, 2022(66): 2200173-2200173

4.Xiaoyun He; Haoyu Li; Ruxin Gao; Chuanhai Zhang; Fei Liang; Yao Sheng; Shujuan Zheng; Jia Xu; Wentao Xu; Kunlun Huang ; Mulberry leaf aqueous extract ameliorates blood glucose and enhances energy expenditure in obese C57BL/6J mice, Journal of Functional Foods, 2019, 63:103505

5. Feng Zhang; Minglan Yang; Jia Xu; Yanzhou Hu; Ruxin Gao; Kunlun Huang; Xiaoyun He ; Coreopsis tinctoria and Its Flavonoids Ameliorate Hyperglycemia in Obese Mice Induced by High-Fat Diet, Nutrients, 2022, 14(6): 1160-1160


二、专利:


三、主要获奖情况: