姓名:李明会

职称:特任副教授

电话:0553-3869297

邮箱:liminghui@ahnu.edu.cn

主要学习工作经历

2007.9 – 2011.6: B.Sc. in Chinese Herbal Medicines, Shandong Agricultural University, Tai’an, China.

2011.9 – 2014.6: M.Sc. in Chemistry of Chinese Herbal Medicines, China Pharmaceutical University, Nanjing, China.

2014.9 – 2018.6: Ph.D. in Biotechnology and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, China.

2023.12 – 2025.1: Visiting Researcher, Medizinische Hochschule Hannover (Hannover Medical School), Hannover, Germany.

2018.7 – Present: Faculty in College of Life Sciences, Anhui Normal University, Wuhu, China.

主要社会兼职

Member, Chinese Society for Cell Biology

Council Member, Anhui Society of Anatomy

Young Editorial Board Member, Chinese Herbal Medicines

主要研究内容

Cellular Metabolic Regulation, Functional Metabolomics, Target Discovery, and Functional Validation in Metabolic Diseases.

Pharmacological Mechanisms of Chinese Herbal Medicines and Natural Products in Preventing and Treating Major Metabolic Diseases.

主要研究课题

1. Natural Science Foundation of China (82405142), 2025-2027, Principal Investigator

2. Natural Science Foundation of Anhui Province (1908085QH342), 2019-2021, Principal Investigator

3. Open Project of Guangxi Key Laboratory of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention, GXXNXG202102, 2021-2023, Principal Investigator

主要研究成果

一、代表性论文及论著

Zhou H#, Sun DD#, Wang DM, Zhu ZR, Hong XL, Fang R, Wang H, Li MH*, Deciphering Metabolic Responses in Traumatic Brain Injury Patients with Different Severity Using 1H NMR-Based Serum Metabolomics, Scientifica. 2025: 5522830.

Li MH#, Meng YY#, Hong XL, Chai H, Huang JY, Wang FG, Zhang WJ, Wang JC, Liu QW*, Xu Y*. Anti-atherosclerotic effect of tetrahydroxy stilbene glucoside via dual-targeting of hepatic lipid metabolisms and aortic M2 macrophage polarization in ApoE-/- mice. J Pharm Biomed Anal. 2024, 248: 116338.

Li MH#, Lu W#, Meng YY, Zhang WJ, Wang FG, Sun L, Xu Y*. Tetrahydroxy Stilbene Glucoside Alleviates Ischemic Stroke by Regulating Conformation-Dependent Intracellular Distribution of PKM2 for M2 Macrophage Polarization. J Agric Food Chem. 2022, 70(49): 15449-15463.

Li MH#, Feng X#, Deng Ba DJ, Chen C, Ruan LY, Xing YX, Chen LY, Zhong GJ*, Wang JS*. Hepatoprotection of Herpetospermum caudigerum Wall. against CCl4-induced liver fibrosis on rats. J Ethnopharmacol. 2019, 229: 1-14.

Li MH, Ruan LY, Chen C, Xing YX, Hong W, Du RH, Wang JS*. Protective effects of Polygonum multiflorum on ischemic stroke rat model analysed by 1H NMR metabolic profiling. J Pharm Biomed Anal. 2018, 155: 91-103.

Li MH#, Du HZ#, Kong GJ, Liu LB, Li XX, Lin SS, Jia AQ, Yuan ST*, Sun L*, Wang JS*. Nuclear Magnetic Resonance-Based Metabolomics Approach to Evaluate the Prevention Effect of Camellia nitidissima Chi on Colitis-Associated Carcinogenesis. Front Pharmacol. 2017, 8: 447.

Li MH, Ruan LY, Zhou JW, Fu YH, Jiang L, Zhao H, Wang JS*. Metabolic profiling of goldfish (Carassius auratis) after long-term glyphosate-based herbicide exposure. Aquat Toxicol. 2017, 188: 159-169.

Li MH, Xu HD, Liu Y, Chen T, Jiang L, Fu YH, Wang JS*. Multi-tissue metabolic responses of goldfish (Carassius auratus) exposed to glyphosate-based herbicide. Toxicol Res (Camb). 2016, 5(4): 1039-1052.

Li MH#, Ruan LY#, Liu Y, Xu HD, Chen T, Fu YH, Jiang L, Wang JS*. Insight into biological system responses in goldfish (Carassius auratus) to multiple doses of avermectin exposure by integrated 1H NMR-based metabolomics. Toxicol Res. 2015, 4(5), 1374-1388.

Li MH, Wang JS*, Lu ZG, Wei DD, Yang MH, Kong LY*. NMR-based metabolomics approach to study the toxicity of lambda-cyhalothrin to goldfish (Carassius auratus). Aquat Toxicol. 2014, 146: 82-92.

Li TX, Liang JX, Liu LL, Shi FC, Jia XW, Li MH*, Xu CP*. Novel kojic acid derivatives with anti-inflammatory effects from Aspergillus versicolor. Fitoterapia. 2021, 154: 105027.

Yang L#, Li MH#, Shen M, Bu S, Zhu B, He F, Zhang XP, Gao X*, Xiao JX*. Chromosome-level genome assembly and annotation of the native Chinese wild blueberry Vaccinium bracteatum. Fruit Res. 2022, 2(1), 1-14.

Ruan LY#, Li MH#, Xing YX, Hong W, Chen C, Chen JF, Xu H, Zhao WL, Wang JS*. Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund. as two sides of the same biological coin. J Ethnopharmacol. 2019, 230: 81-94.

Feng X#, Li MH#, Xia J, Deng Ba DJ, Ruan LY, Xing YX, Chen C, Wang JS*, Zhong GJ*. Tibetan Medical Formula Shi-Wei-Gan-Ning-Pill Protects Against Carbon Tetrachloride-Induced Liver Fibrosis - An NMR-Based Metabolic Profiling. Front Pharmacol. 2018, 9: 965.

Xing YX#, Li MH#, Tao L, Ruan LY, Hong W, Chen C, Zhao WL, Xu H, Chen JF, Wang JS*. Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by 1H NMR Based Metabolic Profiling. J Proteome Res. 2018, 17(5): 1943-1952.

Lu ZG#, Li MH#, Wang JS*, Wei DD, Liu QW, Kong LY*. Developmental toxicity and neurotoxicity of two matrine-type alkaloids, matrine and sophocarpine, in zebrafish (Danio rerio) embryos/larvae. Reprod Toxicol. 2014, 47: 33-41.

李明会, 阮玲玉, 赵文龙, 孟辉辉, 汪俊松*. 基于代谢组学/药动学整合策略的多组分中药药效物质基础研究. 世界科学技术-中医药现代化. 2018, 8: 1471-1475.


Highly motivated candidates with a genuine passion for scientific research are warmly encouraged to join our lab!