| 姓名:谭小娟 职称:副教授 电话:0553-3869297 邮箱:xjtan@ahnu.edu.cn |
◆ 主要学习工作经历
●2016年1月,南京理工大学,博士学位
●2019年至今,安徽师范大学,生命科学学院
●2016年2月至2019年1月,国外博士后
◆ 主要社会兼职
●安徽省细胞生物学学会 会员
●安徽师范大学科技协会 会员
◆ 主要研究内容
病原菌耐药机制及非经典抗菌靶标研究
慢性伤口细菌生物被膜形成的分子机制和诊断标志物研究
水稻生防菌筛选和分子机制研究
◆ 主要研究课题
1.国家自然科学基金青年项目,碱性磷酸酶LapA在慢性伤口铜绿假单胞菌生物被膜形成中的调控机制,32200152,2023.01-2025.12,在研,主持。
2. 安徽省自然科学基金青年项目,慢性伤口铜绿假单胞菌生物被膜形成相关sRNA筛选、鉴定及作用机理研究,2108085QC92,2021.01-2022.12,在研,主持。
3.分子酶学与重大疾病机理研究安徽省重点实验室开放课题,慢性伤口铜绿假单胞菌生物被膜的诊断标志物研究,fzmx202005,2021.01-2023.12,在研,主持。
4. 安徽省科技重大专项项目,皖江流域水稻病虫害绿色防控体系的建立、集成与示范,202003a06020009,2020/10-2023/09,在研,参与。
5. 安徽省高校自然科学研究重点项目,慢性皮肤伤口表皮葡萄球菌生物被膜的诊断标志物研究,KJ2019A0505,2019.01-2021.12,结题,主持。
6. 安徽师范大学博士科研启动金项目,慢性伤口金黄色葡萄球菌生物被膜的诊断标志物研究,2020/01-2022/12,在研,主持。
◆ 主要研究成果
一、代表性论文及论著:
1. Xiaojuan Tan*, Xi Cheng, Jingjing Xiao, Qianqian Liu, Dongsheng Du, Minghui Li, Yang Sun, Jinwei Zhou*, Guoping Zhu*. Alkaline phosphatase LapA regulates quorum sensing–mediated virulence and biofilm formation in Pseudomonas aeruginosa PAO1 under phosphate depletion stress, Microbiology Spectrum, 2023, 11(6): e0206023
2. Xiaojuan Tan*, Mei Hu, Xi Cheng, Jingjing Xiao, Jinwei Zhou*, Guoping Zhu*. Effects of elevated levels of intracellular nitric oxide on Pseudomonas aeruginosa biofilm in chronic skin wound and slow-killing infection models, International Microbiology, 2023
3. Xiao-Juan Tan, Zhi-Wei Zhang, Jing-Jing Xiao, Wei Wang, Feng He, Xuan Gao, Bin Jiang, Liang Shen, Xu Wang, Yang Sun*, Guo-Ping Zhu*. Genomic and phenotypic biology of a novel Dickeya zeae WH1 isolated from rice in China: Insights into pathogenicity and virulence factors, Frontiers in Microbiology, 2022, 13: 997486.
4. Xiaojuan Tan*, Xi Cheng, Mei Hu, Yifan Zhang, Aiqun Jia, Jinwei Zhou*, Guoping Zhu*. Transcriptional analysis and target genes discovery of Pseudomonas aeruginosa biofilm developed ex vivo chronic wound model. AMB Express, 11, 157 (2021).
5. Jinwei Zhou, Aiqun Jia*, Huan Jiang, Peili Li, Hong Chen, Xiaojuan Tan*, Enqi Liu*. 1-(4-Amino-2-hydroxyphenyl) ethanone from Phomopsis liquidambari showed quorum sensing inhibitory activity against Pseudomonas aeruginosa. Applied Microbiology and Biotechnology, 2021, 105:341–352.
6. Jinwei Zhou, Aiqun Jia*, Xiaojuan Tan*, Hong Chen, Bing Sun, Tianzi Huang, Yu He, Peili Li, Enqi Liu*, 1-(4-Amino-2-hydroxyphenyl) ethanone suppresses Agrobacterium tumefaciens virulence and metabolism, Frontiers in Microbiology, 2020, 11,584767.
7. Yi Wang, Xiaojuan Tan, Chuanwu Xi, K. Scott Phillips*. Removal of Staphylococcus aureus from skin using a combination antibiofilm approach. NPJ Biofilms and Microbiomes, 2018, 4, 16.
8. Xiaojuan Tan#, Nan Qin#, Chunyan Wu, Jiyang Sheng, Rui Yang, Beiwen Zheng, Lin Liu, Xinhua Peng*, Aiqun Jia*. Transcriptome analysis of the biofilm formed by methicillin-susceptible Staphylococcus aureus. Scientific Reports, 2015, 5, 11997.
9. Nan Qin#, Xiaojuan Tan#, Yinming Jiao#, Lin Liu, Wangsheng Zhao, Shuang Yang, Aiqun Jia*. RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol. Scientific Reports, 2014, 4, 5467.
10. Xiaojuan Tan#, Lin Liu#, Shili Liu, Dongting Yang, Yikun Liu, Shuang Yang, AiqunJia*, Nan Qin*. Genome of Staphylococcus xylosus and Comparison with S. aureus and S. epidermidis. Journal of Genetics and Genomics, 2014, 41:413-416.
11. Xiaojuan Tan, Dongting Yang, Guoxu Yang, Jinhui Chen, Wei Dong, Jisen Shi, AiqunJia*. The investigation of inhibiting quorum sensing and methicillin-resistant Staphylococcus aureus biofilm formation from Liriodendron hybrid. Pakistan Journal of Pharmaceutical Sciences, 2015, 28:903-908.
12. 刘琳#, 谭小娟#,贾爱群*.细菌群体感应与细菌生物被膜形成之间的关系.微生物学报, 2012, 52, 271-278.