姓名：赵健元 职称：博士生导师，研究员 电话：13917603243 邮箱：zhaojy@vip.163.com

◆ 主要学习工作经历

●主要工作经历：

2022.03- 至今：上海交通大学医学院附属新华医院（引进人才），教育部和上海市环境与儿童健康重点实验室副主任、人力资源部主任、党委教师工作委员会办公室主任、学科人才党支部书记

2013.09-2022.02：复旦大学生命科学学院（引进人才），研究员、博导；复旦大学附属中山医院，双聘教授

2011.11-2013.08：美国The Johns Hopkins University，博士后（导师：陶元祥）

2006.10-2007.01：美国Fred Hutchinson Cancer Research Center，访问学者（导师： Linial Maxine）

2006.07-2008.09：安徽省体育局，助理研究员

●主要学习经历：

2008.09-2011.07：复旦大学，生命科学学院，遗传学，博士（导师：王红艳、金力）

2003.09-2006.07：安徽大学，生命科学学院，生化分子生物学，硕士（导师：李进华）

1999.09-2003.07：安徽大学，生命科学学院，生物技术，本科

◆ 主要社会兼职

1.国家卫健委新生儿疾病重点实验室 学术委员

2.中国环境诱变剂学会致畸专业委员会 副主任委员

3.中国生理学会循环生理专业委员会 委员

4.国际心脏研究会中国转化医学工作委员会 委员

5.上海医学遗传学专科分会青年委员会 委员

◆ 主要研究内容

研究方向为营养代谢失调致发育相关疾病的分子机制。以代谢调控细胞信号为切入点，探讨代谢酶、代谢物失调在出生缺陷、心血管病等复杂疾病的发病机制。

◆ 主要研究课题

1. 揭示影响叶酸发挥心脏发育保护效应的代谢机制，为精准补服叶酸提供理论基础

2. 鉴定出系列先心病新的母孕期致病代谢物，阐明其调控细胞信号的分子机理，系统建立中国人群先心病相关的功能代谢物谱

3. 揭示诱发心肌纤维化的代谢因素及其分子机制，为基于代谢干预延缓心脏疾病不良转归指引方向

◆ 主要研究成果

一、代表性论文及论著：

1.Wang J, … Wang F^#, Gui YH^#, Tao H^#, Zhao JY^#. NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to-mesenchymal transition in mice. Nature Communications 2024; 15(1):9945. doi: 10.1038/s41467-024-54407-7. (IF: 17.69) 作为Featured article入选From molecules and cells to organisms精选集

2.Cai K, … Gui YH^#, Shi Y^#, Zhao JY^#. Maternal folic acid over-supplementation impairs cardiac function in mice offspring by inhibiting SOD1 expression. Cardiovascular Research 2024;120(16):2092-2103. doi: 10.1093/cvr/cvae203. (IF: 13.08) 封面论文、Editor’s Choice

3.Ding JF, … Yang JJ^#, Zhao JY^#, Tao H^#. Epitranscriptomic regulation of cardiac fibrosis via YTHDF1-dependent PIEZO2 mRNA m6A modification Cardiovascular Research 2024; Nov 5:cvae239. (IF: 13.08) Cardiovas Res同期Invited editorial专文评述

4.Zhou ZY, … Tao H^#, Zhao JY^#. Branched-chain amino acids deficiency promotes diabetic cardiomyopathy by activating autophagy of cardiac fibroblasts. Theranostics 2024;14(19):7333-7348. (IF: 12.4)

5.Zhou ZY, … Pan ZQ^#, Cao J^#, Lin FQ^#, Zhao JY^#. Branched-Chain Amino Acids Deficiency Promotes Diabetic Neuropathic Pain Through Upregulating LAT1 and Inhibiting Kv1.2 Channel. Advanced Science 2024;e2402086. (IF: 17.52)

6.Shi JW, … Zhao JY^#, Li MQ^#. TNFSF14⁺ natural killer cells prevent spontaneous abortion by restricting leucine-mediated decidual stromal cell senescence. The EMBO Journal 2024;doi: 10.1038/s44318-024-00220-3. (IF: 9.4)

7.Liu ZY, … Yang JJ^#, Zhao JY^#, Tao H^#. N6-Methyladenosine-mediated phase separation suppresses NOTCH1 expression and promotes mitochondrial fission in diabetic cardiac fibrosis. Cardiovascular Diabetology 2024;23(1):347. doi: 10.1186/s12933-024-02444-3. (IF: 8.5)

8.Chen J, … Zhao JY^#, Zhu T^#, Sun L^#, Fan G^#. Lactylated Apolipoprotein C-II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis. Advanced Science 2024;e2406333. (IF: 17.52)

9.Xiang H, … Xu C^#, Zhou Y^#, Gu J^#, Zhao JY^#, Hou Y^#, Ding C^#. Proteogenomic insights into the biology and treatment of pan-melanoma. Cell Discovery 2024;10(1):78. doi: 10.1038/s41421-024-00688-7. (IF: 38.08)

10.Yin YN, …. Zhao R^#, Sun K^#, Ding C^#, Zhao JY^#. Proteome profiling of early gestational plasma reveals novel biomarkers of congenital heart disease. EMBO Molecular Medicine. 2023; e17745. (IF: 14.26) EMBO Mol Med同期News & Views专文评述

11.Zhao R, … Zhou XY^#, Cao J^#, Sun K^#, Zhao JY^#. Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease. Cell Reports Medicine 2023; 4(3):100953. (IF: 16.99) Cell Rep Med同期Preview专文评述

12.Zhao R, … Tao H^#, Zhao SM^#, Zhao JY^#. Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response. Cell Reports 2023; 42(4):112400. (IF: 9.99)

13.Tang L, … Zhao JY^#, Jin L^#. Dysregulated Gln-Glu-α-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage. Cell Reports Medicine 2023; doi:10.1016/j.xcrm.2023.101026. (IF: 16.99)

14.Hu S, … Zhao JY^#, Xu W^#, Zhao SM^#. Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle. Nature Metabolism 2023;5(4):626-641. (IF: 19.74)

15.Yao Z, …Hou J^#, Guo J^#, Zhao JY^#, Hou Y^#, Ding C^#. Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ. Nature Communications 2023 Jul 17; 14(1):5670. (IF: 17.69) 作为Featured article入选Nature系列Cancer at Nature Portfolio和Focus Cancer精选集

16.Wang Y, … Zhang X^#, Zhao JY^#, Hou Y^#, Ding C^#. Proteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms. Nature Communications 2023;14(1):505. (IF: 17.69)

17.Zhang H, … Zhao JY^#, Qu Y^#, Ye D^#, Ding C^#. Proteogenomics of clear cell renal cell carcinoma response to tyrosine kinase inhibitor. Nature Communications 2023 Jul 17;14(1):4274. (IF: 17.69)

18.Li L, … Zhao JY^#, Hou Y^#, Ding C^#. Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes. Nature Communications 2023;14(1):1751. (IF: 17.69)

19.Li L, … Zhou P^#, Zhao JY^#, Hou Y^#, Ding C^#. Integrative proteogenomic characterization of early esophageal cancer. Nature Communications 2023;14(1):1666. (IF: 17.69)

20.Qu Y, … Zhao JY^#, Zhang H^#, Ye D^#, Ding C^#. Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma. Cell Reports Medicine 2023;doi: 10.1016/j.xcrm.2023.101166. (IF: 16.99)

21.Deng M, … Xu C^#, Shi G^#, Ji Y^#, Zhao JY^#, Zhou J^#, Fan J^#, Hou Y^#, Ding C^#. Proteogenomic Characterization of Cholangiocarcinoma. Hepatology 2023;77(2):411-429. (IF: 17.3)

22.Zhang X, … Gui YH^#, Zhao JY^#. Gestational Leucylation Suppresses Embryonic T-Box Transcription Factor 5 Signal and Causes Congenital Heart Disease. Advanced Science. 2022; 9(15):e2201034. (IF: 17.52) ESI高被引论文

23.Cai K, … Gui YH^#, Zhao JY^#. Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-CoA Hydratase 1 Deficiency. JACC-Basic to Translational Science 2022;7(4):348-362. (IF: 9.53) JACC-BTS同期Editorial Comment专文评述，ESI高被引论文

24.Zhou WJ, … Zhao JY^#, Jin LP^#, Li MQ^#. Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2+ macrophage differentiation. Science Advances 2022;8(8):eabj2488. (IF: 14.96)

25.Li C, … Zhao JY^#, Wang H^#. Master MicroRNA-222 Regulates Cardiac MicroRNA Maturation and Triggers Tetralogy of Fallot. Signal Transduction and Targeted Therapy 2022;7:165. (IF: 38.1)

26.Hu SH, … Zhao JY^#, Xu W^#, Zhao SM^#. Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake. Cell Reports 2022;38(11):110509. (IF: 9.99)

27.Li Y, … Liu T^#, Shen K^#, Zhao JY^#, Hou Y^#, Ding C^#. Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals new therapeutic strategies. Nature Communications 2022; 29;13(1):5723. (IF: 17.69)

28.Qu Y, … Zhang H^#, Zhao JY^#, Ye D^#, Ding C^#. A Proteogenomic Analysis of Clear Cell Renal Cell Carcinoma in a Chinese Population. Nature Communications 2022;13(1):2052. (IF: 17.69)

29.Qu Y, … Zhao JY^#, Zhang H^#, Ye D^#, Ding C^#. Proteogenomic characterization of MiT family translocation renal cell carcinoma. Nature Communications 2022;13(1):7494. (IF: 17.69) Nat Rev Urol 2023 Research highlights专文评述

30.Shen Y, … Zhao JY^#, Cheng L^#. Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α. Cell Death & Disease 2022;13(7):643. (IF: 9.69)

31.Zhang Y, … Jin L^#, Zhao JY^#, Zhou X^#. Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice. Cell Death & Disease 2022;13(3):279. (IF: 9.69)

32.Zhou Y, … Zhang Y^#, Zhao JY^#, Tao H^#. METTL3 boosts glycolysis and cardiac fibroblast proliferation by increasing AR methylation. International Journal of Biological Macromolecules 2022;223(A):899-915. (IF: 8.03)

33.Sun H, … Zhao JY^#, Zhang Y^#, Tao H^#. MTHFR epigenetic derepression protects against diabetes cardiac fibrosis. Free Radical Biology and Medicine 2022;193(1):330-341. (IF: 8.1)

34.Zhang X, … Zhao JY^#. Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation. Cell Reports 2021;37(2):109821. (IF: 9.99) ESI高被引论文

35.Wang XH, … Jin LP^#, Zhao JY^#. Low embryonic villous succinate accumulation increases recurrent spontaneous abortion risk. Nature Communications 2021;12(1):3428. (IF: 17.69) ESI高被引论文

36.Xu S, … Zhao JY^#. Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Signal Transduction and Targeted Therapy 2021;6(1):54. (IF: 38.1) ESI高被引论文，入选2023年度中华医学科技论文TOP100

37.Zhang Y, … Zhao JY^#, Zhou XY^#. Two sides of NNMT in alcoholic and nonalcoholic fatty liver development. Journal of Hepatology 2021;74(5):1250-1253. (IF: 30.08)

38.Xu W, … Zhao JY^#, Zhang H^#, Ye D^#. Adenylate cyclase-activating polypeptide 1 gene methylation predicts prognosis and the immune microenvironment of bladder cancer. Clinical and Translational Medicine 2021;11:e597. (IF: 8.55)

39.Qu YY, … Ye DW^#, Zhao SM^#, Zhao JY^#. Inactivation of the AMPK-GATA3-ECHS1 Pathway Induces Fatty Acid Synthesis That Promotes Clear Cell Renal Cell Carcinoma Growth. Cancer Research 2020; 80(2):319-333. (IF: 13.31)

40.Mei X, … Wang H^#, Zhao JY^#, Zhao S^#, Xu W^#. Inhibiting MARSs reduces hyperhomocysteinemia-associated neural tube and congenital heart defects. EMBO Molecular Medicine 2020; 12(3):e9469. (IF: 14.26)

41.Li Y, … Zhao SM^#, Zhao JY^#. APC/C^CDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression. Nature Communications 2019; 10(1):2502. (IF: 17.69)

42.Wang D, … Zhao SM^#, Zhao JY^#. Colonic lysine homocysteinylation induced by high-fat diet suppresses DNA damage repair. Cell Reports 2018; 25:398-412. (IF: 9.99) Trends Cancer 2019 Spotlight专文评述

43.Wang D, … Zhao SM^#, Wang H^#, Zhao JY^#. Lower circulating folate induced by a Fidgetin intronic variant is associated with reduced congenital heart disease Susceptibility. Circulation 2017; 135(18):1733-1748. (IF: 39.92)

44.Xu S, … Zhao JY^#, Zhao SM^#. Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation. Signal Transduction and Targeted Therapy 2017; 2, e16035. (IF: 38.1)

45.Zhao JY*, Liang L*, Gu X*, …Tao YX^#. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nature Communications 2017; 8:14712. (IF: 17.69)

46.Xu JT*, Zhao JY*, Zhao X*, … Tao YX^#. Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia. Journal of Clinical Investigation 2014; 124(2):592-603. (IF: 19.46) JCI同期Editor’s Picks专文评述

47.Zhao JY*, Qiao B*, Duan WY*, … Huang GY^#, Jin L^#, Wang HY^#. Genetic variants reducing MTR gene expression increase the risk of congenital heart disease in Han Chinese populations. European Heart Journal 2014; 35(11):733-42. (IF: 35.86) 封面论文

48.Zhao X*, Tang Z*, Zhang H*, Atianjoh FE*, Zhao JY*, … Tao YX^#. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nature Neuroscience 2013; 16(8):1024-31. (IF: 28.77) Nat Neurosci同期News and Views专文评述，ESI高被引论文

49.Zhao JY*, Yang XY*, Shi KH*, … Wang HY^#. A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population. Cell Research 2013, 23:242-253. (IF: 46.3)

50.Zhao JY*, Yang XY*, Gong XH*, … Qiao B^#, Wang HY^#. Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population. Circulation 2012; 125(3):482-90. (IF: 39.92) 入选Circulation“近两年最重要论文”（2012）和“先心病领域热度佳作”（2013）

二、专利：

1. 用于孕早期诊断胎儿先天性心脏病的外周血标志代谢物，申请号202211259071.

2. ECHS1抑制剂的用途，申请号202210893451.

三、主要获奖情况：

1.高等学校科学研究优秀成果奖，自然科学一等奖，“中国人群重大出生缺陷的遗传分析”，第三完成人，2015年

2.全国妇幼健康科学技术奖，自然科学一等奖，“新发突变致出生缺陷的发生机理”，第四完成人，2015年

3.其他：复旦大学卓识杰出人才（2020年）、复旦鸿翼奖教金一等奖（2018年）、复旦大学生命科学学院院长奖（2018年）、复星奖教金特等奖（2017年）、上海市优秀博士论文（2014年）、罗氏诊断奖（2013年）