◆ 主要学习工作经历

·2008.09-2011.07：复旦大学，生命科学学院，遗传学，博士（导师：王红艳、金力）

·2003.09-2006.07：安徽大学，生命科学学院，生化分子生物学，硕士（导师：李进华）

·1999.09-2003.07：安徽大学，生命科学学院，生物技术，本科

◆ 主要社会兼职

·国家卫健委新生儿疾病重点实验室 学术委员

·中国环境诱变剂学会致畸专业委员会 副主任委员

·中国生理学会循环生理专业委员会 委员

·中国遗传学会心血管遗传专业委员会 委员

·上海医学遗传学专科分会青年委员会 委员

◆ 主要研究内容

研究方向为营养代谢失调致发育相关疾病的分子机制，在心血管病、出生缺陷、肿瘤等复杂疾病的发病机制研究中取得系列高水平研究成果。以通讯或第一作者（含共同）发表SCI论文60篇，篇均影响因子15.4（其中IF>10论文35篇），包括Circulation（2篇）、Eur Heart J、Nat Commun（11篇）、Nat Neurosci、Nat Metab、Cell Rep（4篇）、Cell Rep Med（3篇）、Cell Res、STTT（3篇）、Embo Mol Med（2篇）、J Hepatol、Hepatology、JCI等，其中6篇论文入选ESI高被引论文，10篇论文获专文评述，被引超3200次，h指数31，i10指数54。近五年获批十余项省部级项目，主持国家自然科学基金重点项目、优青、面上和863青年科学家专项等项目，获基金委创新群体、国家重大研究计划和重点研发计划资助（骨干）；作为主要完成人获教育部自然科学一等奖和国家妇幼健康科学技术一等奖。

◆ 主要研究课题

1. 孕期营养代谢物失调致子代先天性心脏病的分子机制

2. 孕期胆酸失调抑制子代先天性心脏病的分子机制

3. 代谢物信号失调致先天性心脏病的分子机制

◆ 主要研究成果

一、代表性论文及论著：

1.Chen YL，Tang LC, Zhou W…. Zhao JY^#. Endometrial Stromal Cell-Derived TMAO Sustains Decidualization to Prevent Recurrent Spontaneous Abortion. Cell Metabolism. 2025 Nov26（接收）.

2.Zhang YS*, Liu ZY*, Lin LC, Tu B, Mao S, Song K, Liu P, Yang JJ^#, Chen Q^#, Zhao JY^#, Tao H^#. Epigenetic blockade of SOD2 boosts mitochondria ROS and cytoskeleton remodeling in cardiac fibrosis. Cardiovascular Research. 2025 Nov 18:cvaf257. doi: 10.1093/cvr/cvaf257(IF=13.3)

3.Tu B*, Song K*, Zhou ZY*, Lin LC, Liu ZY, Sun H, Zhou Y, Sha JM, Shi Y, Yang JJ^#, Zhang Y^#, Zhao JY^#, Tao H^#. SLC31A1 loss depletes mitochondrial copper and promotes cardiac fibrosis. Eur Heart J. 2025 Jul 1;46(25):2458-2474. （IF=35.6）

4.Zhou ZY*, Wang JY*, Li ZX, Zheng HL, Zhou YN, Huang LN, Wang LJ, Ding XW, Sun X, Cai K, Zhao R, Shi Y, Chen AF, Pan ZQ, Cao J^#, Lin FQ^#, Zhao JY^#. Branched-Chain Amino Acids Deficiency Promotes Diabetic Neuropathic Pain Through Upregulating LAT1 and Inhibiting Kv1.2 Channel. Adv Sci. 2024 Jul 1:e2402086. doi: 10.1002/advs.202402086. （IF=14.1）

5.Zhou ZY*, Song K*, Liu ZY, Ke YF, Shi Y, Cai K, Zhao R, Sun X, Tao H^#, Zhao JY^#. Branched-chain amino acids deficiency promotes diabetic cardiomyopathy by activating autophagy of cardiac fibroblasts. Theranostics. 2024 Oct 28;14(19):7333-7348. doi: 10.7150/thno.102708 （IF=13.3）

6.Ke Cai*, An-Na Shen*, Feng Wang*, Hai-Qun Shi, Rui Zhao, Hao-Ran Geng, Jia-Quan Lu,Yong-Hao Gui^#, Yan Shi^#, Jian-Yuan Zhao^#. Maternal folic acid over-supplementation impairs cardiac function in mice offspring by inhibiting SOD1 expression. Cardiovascular Research. 2024 Dec 14;120(16):2092-2103. doi: 10.1093/cvr/cvae203

7.Yin YN*, …. Zhao R^#, Sun K^#, Ding C^#, Zhao JY^#. Proteome profiling of early gestational plasma reveals novel biomarkers of congenital heart disease. EMBO Molecular Medicine. 2023; e17745. (IF: 14.26) EMBO Mol Med同期News & Views专文评述

8.Zhao R*, … Zhou XY^#, Cao J^#, Sun K^#, Zhao JY^#. Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease. Cell Reports Medicine 2023; 4(3):100953. (IF: 16.99) Cell Rep Med同期Preview专文评述

9.Zhao R*, … Tao H^#, Zhao SM^#, Zhao JY^#. Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response. Cell Reports 2023; 42(4):112400. (IF: 9.99)

10.Tang L*, … Zhao JY^#, Jin L^#. Dysregulated Gln-Glu-α-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage. Cell Reports Medicine 2023; doi:10.1016/j.xcrm.2023.101026. (IF: 16.99)

11.Hu S*, … Zhao JY^#, Xu W^#, Zhao SM^#. Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle. Nature Metabolism 2023;5(4):626-641. (IF: 19.74)

12.Yao Z, …Hou J^#, Guo J^#, Zhao JY^#, Hou Y^#, Ding C^#. Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ. Nature Communications 2023 Jul 17; 14(1):5670. (IF: 17.69) 作为Featured article入选Nature系列Cancer at Nature Portfolio和Focus Cancer精选集

13.Wang Y*, … Zhang X^#, Zhao JY^#, Hou Y^#, Ding C^#. Proteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms. Nature Communications 2023;14(1):505. (IF: 17.69)

14.Zhang H*, … Zhao JY^#, Qu Y^#, Ye D^#, Ding C^#. Proteogenomics of clear cell renal cell carcinoma response to tyrosine kinase inhibitor. Nature Communications 2023 Jul 17;14(1):4274. (IF: 17.69)

15.Li L*, … Zhao JY^#, Hou Y^#, Ding C^#. Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes. Nature Communications 2023;14(1):1751. (IF: 17.69)

16.Li L*, … Zhou P^#, Zhao JY^#, Hou Y^#, Ding C^#. Integrative proteogenomic characterization of early esophageal cancer. Nature Communications 2023;14(1):1666. (IF: 17.69)

17.Qu Y, … Zhao JY^#, Zhang H^#, Ye D^#, Ding C^#. Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma. Cell Reports Medicine 2023;doi: 10.1016/j.xcrm.2023.101166. (IF: 16.99)

18.Deng M*, … Xu C^#, Shi G^#, Ji Y^#, Zhao JY^#, Zhou J^#, Fan J^#, Hou Y^#, Ding C^#. Proteogenomic Characterization of Cholangiocarcinoma. Hepatology 2023;77(2):411-429. (IF: 17.3)

19.Zhang X*, … Gui YH^#, Zhao JY^#. Gestational Leucylation Suppresses Embryonic T-Box Transcription Factor 5 Signal and Causes Congenital Heart Disease. Advanced Science. 2022; 9(15):e2201034. (IF: 17.52) 入选ESI高被引论文

20.Cai K*, … Gui YH^#, Zhao JY^#. Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-CoA Hydratase 1 Deficiency. JACC-Basic to Translational Science 2022;7(4):348-362. (IF: 9.53) JACC-BTS同期Editorial Comment专文评述，入选ESI高被引论文

21.Zhou WJ*, … Zhao JY^#, Jin LP^#, Li MQ^#. Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2+ macrophage differentiation. Science Advances 2022;8(8):eabj2488. (IF: 14.96)

22.Li C*, … Zhao JY^#, Wang H^#. Master MicroRNA-222 Regulates Cardiac MicroRNA Maturation and Triggers Tetralogy of Fallot. Signal Transduction and Targeted Therapy 2022;7:165. (IF: 38.1)

23.Hu SH*, … Zhao JY^#, Xu W^#, Zhao SM^#. Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake. Cell Reports 2022;38(11):110509. (IF: 9.99)

24.Li Y*, … Liu T^#, Shen K^#, Zhao JY^#, Hou Y^#, Ding C^#. Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals new therapeutic strategies. Nature Communications 2022; 29;13(1):5723. (IF: 17.69)

25.Qu Y*, … Zhang H^#, Zhao JY^#, Ye D^#, Ding C^#. A Proteogenomic Analysis of Clear Cell Renal Cell Carcinoma in a Chinese Population. Nature Communications 2022;13(1):2052. (IF: 17.69)

26.Qu Y*, … Zhao JY^#, Zhang H^#, Ye D^#, Ding C^#. Proteogenomic characterization of MiT family translocation renal cell carcinoma. Nature Communications 2022;13(1):7494. (IF: 17.69) Nat Rev Urol 2023 Research highlights专文评述

27.Shen Y, … Zhao JY^#, Cheng L^#. Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α. Cell Death & Disease 2022;13(7):643. (IF: 9.69)

28.Zhang Y*, … Jin L^#, Zhao JY^#, Zhou X^#. Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice. Cell Death & Disease 2022;13(3):279. (IF: 9.69)

29.Zhou Y*, … Zhang Y^#, Zhao JY^#, Tao H^#. METTL3 boosts glycolysis and cardiac fibroblast proliferation by increasing AR methylation. International Journal of Biological Macromolecules 2022;223(A):899-915. (IF: 8.03)

30.Sun H*, … Zhao JY^#, Zhang Y^#, Tao H^#. MTHFR epigenetic derepression protects against diabetes cardiac fibrosis. Free Radical Biology and Medicine 2022;193(1):330-341. (IF: 8.1)

31.Zhang X, … Zhao JY^#. Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation. Cell Reports 2021;37(2):109821. (IF: 9.99) 入选ESI高被引论文

32.Wang XH*, … Jin LP^#, Zhao JY^#. Low embryonic villous succinate accumulation increases recurrent spontaneous abortion risk. Nature Communications 2021;12(1):3428. (IF: 17.69) 入选ESI高被引论文

33.Xu S, … Zhao JY^#. Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Signal Transduction and Targeted Therapy 2021;6(1):54. (IF: 38.1) 入选ESI高被引论文，入选2023年度中华医学科技论文TOP100

34.Zhang Y*, … Zhao JY^#, Zhou XY^#. Two sides of NNMT in alcoholic and nonalcoholic fatty liver development. Journal of Hepatology 2021;74(5):1250-1253. (IF: 30.08)

35.Xu W*, … Zhao JY^#, Zhang H^#, Ye D^#. Adenylate cyclase-activating polypeptide 1 gene methylation predicts prognosis and the immune microenvironment of bladder cancer. Clinical and Translational Medicine 2021;11:e597. (IF: 8.55)

36.Qu YY*, … Ye DW^#, Zhao SM^#, Zhao JY^#. Inactivation of the AMPK-GATA3-ECHS1 Pathway Induces Fatty Acid Synthesis That Promotes Clear Cell Renal Cell Carcinoma Growth. Cancer Research 2020; 80(2):319-333. (IF: 13.31)

37.Mei X*, … Wang H^#, Zhao JY^#, Zhao S^#, Xu W^#. Inhibiting MARSs reduces hyperhomocysteinemia-associated neural tube and congenital heart defects. EMBO Molecular Medicine 2020; 12(3):e9469. (IF: 14.26)

38.Li Y*, … Zhao SM^#, Zhao JY^#. APC/C^CDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression. Nature Communications 2019; 10(1):2502. (IF: 17.69)

39.Wang D*, … Zhao SM^#, Zhao JY^#. Colonic lysine homocysteinylation induced by high-fat diet suppresses DNA damage repair. Cell Reports 2018; 25:398-412. (IF: 9.99) Trends Cancer 2019 Spotlight专文评述

40.Wang D*, … Zhao SM^#, Wang H^#, Zhao JY^#. Lower circulating folate induced by a Fidgetin intronic variant is associated with reduced congenital heart disease Susceptibility. Circulation 2017; 135(18):1733-1748. (IF: 39.92)

41.Xu S*, … Zhao JY^#, Zhao SM^#. Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation. Signal Transduction and Targeted Therapy 2017; 2, e16035. (IF: 38.1)

42.Zhao JY*, Liang L*, Gu X*, …Tao YX^#. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nature Communications 2017; 8:14712. (IF: 17.69)

43.Xu JT*, Zhao JY*, Zhao X*, … Tao YX^#. Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia. Journal of Clinical Investigation 2014; 124(2):592-603. (IF: 19.46) JCI同期Editor’s Picks专文评述

44.Zhao JY*, Qiao B*, Duan WY*, … Huang GY^#, Jin L^#, Wang HY^#. Genetic variants reducing MTR gene expression increase the risk of congenital heart disease in Han Chinese populations. European Heart Journal 2014; 35(11):733-42. (IF: 35.86)

45.Zhao X*, Tang Z*, Zhang H*, Atianjoh FE*, Zhao JY*, … Tao YX^#. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nature Neuroscience 2013; 16(8):1024-31. (IF: 28.77) Nat Neurosci同期News and Views专文评述，入选ESI高被引论文

46.Zhao JY*, Yang XY*, Shi KH*, … Wang HY^#. A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population. Cell Research 2013, 23:242-253. (IF: 46.3)

47.Zhao JY*, Yang XY*, Gong XH*, … Qiao B^#, Wang HY^#. Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population. Circulation 2012; 125(3):482-90. (IF: 39.92) 入选Circulation“近两年最重要论文”（2012）和“先心病领域热度佳作”（2013）

二、专利：

1.

三、主要获奖情况：

1. 高等学校科学研究优秀成果奖，自然科学一等奖，“中国人群重大出生缺陷的遗传分析”，第三完成人，2015年

2. 全国妇幼健康科学技术奖，自然科学一等奖，“新发突变致出生缺陷的发生机理”，第四完成人，2015年

3. 其他：复旦大学卓识杰出人才（2020年）、复旦鸿翼奖教金一等奖（2018年）、复旦大学生命科学学院院长奖（2018年）、复星奖教金特等奖（2017年）、上海市优秀博士论文（2014年）、罗氏诊断奖（2013年）