·   姓名:蔡亚非

·   职称:教授

·   电话:0553-3869297

·   邮箱:caiyafeinau@163.com

◆主要学习工作经历

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·   生理学专业博士生导师。1993,7毕业于安徽师范大学生物学系生物学专业毕业,获学士学位; 1996,7毕业于安徽师范大学生物学系动物学专业毕业,获硕士学位;2005,7毕业于南京农业大学动物科技学院动物遗传育种与繁殖专业毕业,获博士学位;2013,1-2016,4 在美国佐治亚医学院生化与分子生物学系从事博士后研究;19967月于安徽师范大学工作至今。2010.6-2011.6驻安徽三缘养殖实业有限责任公司——安徽省第三批企业科技特派员(兼职)2009.6-2010.6驻芜湖卫岗乳业有限公司——安徽省首批企业科技特派员(脱产)。

◆主要社会兼职

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·   安徽解剖学会副理事长

·   安徽生理学会常务理事

◆主要研究内容

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·   再生生理学:以模式动物为研究对象,筛选与脊髓损伤相关基因,研究基因的分布与表达规律,并联合神经干细胞移植进行基因治疗,研究脊髓再生形态学及分子生物学特征。为脊髓再生和功能恢复的临床研究提供理论依据,最终为治疗开辟新途径; 应用生理学:以畜禽为研究对象,研究影响动物生产性状的主效基因、数量性状位点QTL及表观遗传学特征等,筛选分子遗传标记,加以推广应用。

◆主要研究课题

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·   主持国家自然科学基金面上项目2项:(1)“Smad9基因在鹅卵巢等级建立中的作用”,2016年度国家自然基金面上项目,(No 31572265),2016-201725万; 2 CIBZ基因在神经干细胞移植靶向性修复小鼠脊髓损伤中的作用”,2014年度国家自然基金面上项目(No 31372207),2014-2017, 92万(含配套12万)。

·   主持省级课题4项:(1 “鹅卵巢启动相关基因Smad9遗传特性及功能分析”,2012年度安徽省自然科学基金(1208085MC41),2012-2014 2 “皖江白鹅近交系数的控制及保种核心群的建立”,2010年度安徽省科技人员服务企业计划项目(No. 10020303043) 3 “高产皖江白鹅核心种群及养殖配套体系的建立”,2009年度安徽省自然科学研究重点项目(No KJ2009A039)20092011;(4 LBP基因基因LPS结合区遗传特性及功能解析---以奶牛乳腺炎为例”,2013年度安徽省自然科学研究重点项目,2013-2014

◆主要研究成果

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1、代表性论文(20篇以内,*号为通讯作者):

·   Cai Y, Pi W, Sivaprakasam S, Zhu X, Zhang M, Chen J, et al. UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development. PLoS Genet, 2015, 11(11): e1005643.

·   Teng Y, Cai Y, Pi W, Gao L, Shay C.Augmentation of the anticancer activity of CYT997 in human prostate cancer by inhibiting Src activity. J Hematol Oncol. 2017; 10(1):118.

·   Miller C, Cai Y, Patton T, Graves SH, Li H, Sabbatini ME. RCAD/BiP pathway is necessary for the proper synthesis of digestive enzymes and secretory function of the exocrine pancreas. Am J Physiol Gastrointest Liver Physiol. 2017; 312(3):G314-G326

·   Cai Y*, Li J, Zhang Z, Chen J, Zhu Y, Li R, Chen J, Gao L, Liu R, Teng Y.Zbtb38 is a novel target for spinal cord injury. Oncotarget. 2017; 8(28):45356-45366.

·   Zhang Z, Chen J, Chen F, Yu D, Li R, Lv C, Wang H, Li H, Li J*, Cai Y* Tauroursodeoxycholic acid alleviates secondary injury in the spinal cord via up-regulation of CIBZ gene. Cell Stress Chaperones. 2017 Nov 18. doi: 10.1007/s12192-017-0862-1.

·   Lu C, Makala L, Wu D, Cai Y* Targeting Translation: eIF4E as an Emerging Anti-Cancer Drug Target. Expert Reviews in Molecular Medicine, 2016;18 (e2):1-13.

·   Cai Y, Singh N, Li H. Essential role of Ufm1 conjugation in the hematopoietic system. Exp Hematol. 2016 Mar 24. pii: S0301-472X(16)30036-4.

·   Cai Yafei, Li Jun, Yang Shiyong Li Ping, Zhang Xuan, Liu Honglin. CIBZ, a novel BTB domain-containing protein, is involved in mouse spinal cord injury via mitochondrial pathway independent of p53 gene. PLoS ONE, 2012; 7(3): e33156.

·   Huang Pin, Lu Chunwan #, Li Jun ,Xu Jun, Liu Zaiqun, Wang Qiang, Wang Zhao, HuoJiayan, Li Honglin, Teng Yong, Cai Yafei*. Mutations in HSP70-2 gene change the susceptibility to clinical mastitis in Chinese Holstein. Gene, 2015; 559(1):62-72.

·   Li J, Wang Q, Chen F, Wang H, Chen J, Huo J and Cai Y*. SNPs of CD14 change the mastitis morbidity of Chinese Holstein. Molecular Medicine Reports. 2017;16(6):9102-9110.

·   Cheng Jienan, Li Jun, Zhang Wenxin, Cai Yafei*, Wang Genlin. Mutations in lipopolysaccharide-binding protein (LBP) gene change the susceptibility to clinical mastitis in Chinese Holstein. Molecular Biology Reports, 2012; 39(10): 9601-9612.

·   Yang Fan, Li Lian, Liu Huiling, Cai Yafei*, Wang Genlin. Polymorphism in the exon 4 of β-lactoglobulin variant B precursor gene and its association with milk traits and protein structure in Chinese Holstein. Molecular Biology Reports, 2012; 29(4): 3957-3964. 

·   Cai Ya-Fei*, Fan Rui, HuaTian-Miao, Liu Hui-Ling, Li Jing. Nimodipine alleviates apoptosis-mediated impairments through mitochondrial pathway after spinal cord injury. Current Zoology, 2011; 57(3):340-349.

·   Xu Jun, Li Jun #, Wang Haosen #, Wang Guanglin #, Chen Jie, Huang Pin, Cheng Jienan, Gan Lu, Wang Zhao & Cai Yafei*. A novel SMAD family protein, SMAD9 is involved in follicular initiation and changes egg yield of geese via synonymous mutations in exon1 and intron2. Molecular Biology Reports,, 2015; 42:289-302.

·   Chen Jie, Liu Huiling, Cai Yafei*, Wang Genlin, Liu Honglin, Li Jing.Mutations in the exon 10 of Prolactin receptor gene (PRLR) change the egg production performance in Wanjiang White Goose. Molecular Biology Reports, 2012; 39(1): 475-483.

·   Chen Jie, Wang Genlin, Cai Yafei*. High Mutation Rate in PRL Intron 2 Regulates the Egg-laying Performance in the Two-line Hybrid Wanjiang White Goose, Journal of Applied Animal Research, 2011; 39(3):175-180.

·   Liu Huiling, Li Jing, Yang Fan, Cai Yafei*. Molecular Sexing of Endangered Cranes Based on CHD-W gene. Journal of Applied Animal Research, 2011; 39(3): 212-217.

2、专利:

·   蔡亚非;程越;曹枫. 国家发明专利,专利号:200910185011.0

3、主要获奖情况(省部级以上):

·   2012年度第九届安徽青年科技创新奖